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Loss of MEKK4 signaling causes elevations in auditory threshold responses ABR thresholds obtained from WT (blue), heterozygous MEKK4K1361/+ (green), and MEKK4K1361R (red) mutant mice. Thresholds were significantly elevated in MEKK4K1361R mutant mice compared with WT mice at all three tested frequencies. Data are mean ± SEM; n = 3. *p < 0.05. **p < 0.01.
