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. Author manuscript; available in PMC: 2016 May 4.
Published in final edited form as: Annu Rev Anal Chem (Palo Alto Calif). 2015 May 4;8:239–261. doi: 10.1146/annurev-anchem-071114-040426

Figure 2.

Figure 2

(a) Segmented flow–coupled low-flow push-pull probe. Artificial cerebrospinal fluid (aCSF) is infused directly into the tissue, while extracellular fluid is withdrawn at an equal flow rate. Suction for sampling flow is generated by a vacuum applied to the outlet of the Teflon storage tubing, which also pulls the oil to generate the segmented sample stream. (b) Internal tee geometry (tee outline not to scale). (c) Photograph of 6-nL sample segments (blue food dye) entering the storage tubing at the tee outlet. Figure reprinted with permission from Reference 104.