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. 2016 Jan 26;8:9. doi: 10.1186/s13073-016-0263-6

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© Schubert and Kohlbacher. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Fold change in cleavage likelihood and differences in neo-immunogenicity compared for 1000 randomly sampled epitope pairs. Spacers of lengths 1–6 were designed with the described model. The cleavage probability (a) and immunogenicity (b) were compared for epitope pairs concatenated without a spacer sequence, epitope pairs combined with a commonly used spacer sequence (AAY), and pairs combined with optimally designed spacers. Black error bars represent the 68 % confidence intervals