Table 2.
Parameter median (IQR) | ARV-naïve group (n = 18) | Lopinavir group (n = 16) | p value |
---|---|---|---|
Cmax (μg/mL) | 8.76 (7.80–9.84) | 28.15 (14.00–32.95) | <0.0001 |
CV | 26.3 % | 59.6 % | |
Tmax (h) | 42 (42–66) | 67 (51–70) | 0.031 |
CV | 35.5 % | 27.1 % | |
AUC(0-inf) (μg.h/mL) | 445 (357–553) | 2478 (1093–3596) | <0.0001 |
CV | 33.5 % | 71.0 % | |
T1/2 (days) | 4.1 (2.7–4.4) | 4.6 (4.4–5.2) | 0.003 |
CV | 25.7 % | 15.4 % | |
Day-7 conc (ng/mL) | 336 (230–396) | 3170 (1440–5085) | <0.0001 |
CV | 54.0 % | 98.5 % |
Values are shown as medians (interquartile ranges [IQRs]) and Coefficient of variation (CV, %). Cmax, maximal concentration; Tmax, time at the maximal concentration; AUC(0-inf), area under the plasma concentration-time curve, from 0 h to infinity; t1/2, elimination half-life; Day-7 concentration, lumefantrine concentration on day-7;. Statistical significance (p values) calculated using the Kruskal-Wallis test