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Mixed-effects model of the effects of dose occasion, treatment group and covariates on dihydroartemisinin exposure in HIV-1 infected patients
| Dose occasion effect (last/first dose occasion) | AUC GMR (95 % CI) | Cmax GMR (95 % CI) |
| - Antiretroviral naïve group | 1.30 (1.03–1.64) | 1.12 (0.84–1.49) |
| - Lopinavir group | 0.84 (0.65–1.09) | 0.77 (0.56–1.05) |
| Treatment group effect (lopinavir group/naïve group) | ||
| - 0 to 8 h | 1.73 (1.26–2.37) | 1.73 (1.24–2.43) |
| - 60 to 68 h | 1.12 (0.56–1.55) | 1.19 (0.58–2.57) |
