Each infant was assessed for coughing spells/day. Post-therapy, PP (n=4) did not decrease the amount of coughing compared to the group’s pre-study value (A). In contrast, the three treatments of OB (n=6), OP (n=4), and BP (n=5) did decrease the number of coughing episodes per day, but these data only reached statistical significance for the OB group (P=0.028). After open label therapy of bethanacol and omeprazole, the PP group demonstrated a decrease in cough that was similar in magnitude to the OB study period though it did not reach statistical significance (P=0.06, Figure 3B).