Table 3.

Summary of approaches used to estimate egg reduction rates among children infected with schistosomes following treatment with praziquatel

Approach	Method	Required parametric assumptions	Inference
Model-free	Sample statistics	• None	• Population average estimates
Model-based	Marginal models	• Variance to mean relationship • Correlation structure among repeated measures	• Population average estimates • Covariate effects
	Conditional mixed models	• Conditional distribution of data • Distribution of random effects	• Individual estimates • Covariate effects
	Bayesian conditional mixed models	• Conditional distribution of data • Distribution of random effects • Prior distribution of parameters	• Individual estimates • Covariate effects • Fully integrated parameter uncertainty