Table 5. Clinical studies of cannabinoids in epilepsy- pre-2013.

Study	No. of patients	Dose/duration	Results
Mechoulam, Carlini 1978	9 (R, 4 CBD) epilepsy	200 mg/day 3 months	2/4 CBD: seizure free; 0/5 P
Cunha et al., 1980	Phase 1: 16 healthy; R, 8 CBD	200-300 mg/day	Phase 1: 2/8 CBD-somnolence
	Phase 2: R, 15; 2e Gen Epi with TL Focus; 8 CBD		Phase 2: 4/8 CBD-almost sz free
			3/8 partial improvement
			1/7 P seizure free
Ames, Cridland, 1986	12; MR; Intr Epi institutionalized	200 mg/day (open label)	somnolence
Trembly 1990 (abstract only)	12 pts; placebo phase, then R x-over	Placebo 6 mos 300 mg/day	“some benefit”

CBD, cannabidiol; pts, patients.