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Trisomy rescue in a female rob(13q;14q) heterozygote. A disomic 14 oocyte is fertilized by a normal haploid sperm to produce a trisomy 14 conceptus. This is “rescued” by loss of the maternal 14 to produce a carrier zygote with biparental inheritance. Loss of the paternal 14 leads to UPD 14mat (heterodisomy) with both 14s from the mother. Chromosome 13 is shown in black and chromosome 14 in green. Red circles represent maternal centromeres and blue circles paternal centromeres.
