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. 2016 Jan 27;13:20. doi: 10.1186/s12974-016-0477-y

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© Couturier et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Memory deficits are prevented in 5xFAD mice with ASC+/− genotype. Hippocampal-dependent learning and long-term spatial memory were assessed in a modified Morris water maze paradigm. A protocol of three trials/day during 6 days was used as a training period for WT and 5xFAD ASC mice. Results are expressed as the mean latency to reach the platform ± SEM and analyzed by ANOVA for repeated measures, ***P < 0.001 vs F+ A+/+, (a). Probe trial was performed on day 7, and results are expressed as the mean distance to the platform (Gallagher proximity coefficient) ± SEM, and statistical differences were determined using a ANOVA analysis and post Bonferroni multiple comparison test, **P < 0,01 vs F− A+/+, ⁺⁺ P < 0.01 vs F+ A+/− (b) (15 F− A+/+, 14 F+ A+/+, and 11 F+ A+/−)