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. 2016 Jan 27;9:9. doi: 10.1186/s13041-016-0190-x

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© Wu et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — The DAA mutant shows increased pH sensitivity. Representative traces showing acid-activated current of ASIC2a WT, AAD and DAA at different stimulating pH. The plot shows pH sensitivity for the three constructs. pH₅₀ for WT, AAD, and DAA was 4.53 ± 0.07, 4.64 ± 0.15, and 4.99 ± 0.07, respectively. The difference between WT and DAA was significant (p < 0.05). N = 5–6 per construct