Figure 5. Line graphs indicate the effects of systemic subcutaneous injections of 3, 10, and 30 mg/kg of a SORA1 (compound 56: C65), on 20% CO₂-induced changes (from 5 min baseline) in (a) MAP (mm Hg), (b) HR (beats/min, BPM), (d) general locomotor activity (counts/min), and decreased CBT (Celsius) in freely moving rats surgically implanted with radiotelemetry probes. There were no significant differences in baseline MAP, HR, locomotor activity, or CBT (see legends on figures with baselines ± SEM). Gray shaded area represents the 5 min CO₂ or atmospheric air challenge, where atmospheric air was also infused prior to and after for 5 min (also indicated at bottom of x-axis). Bar graphs indicate the effects of systemic subcutaneous injections of 3,1,0 and 30 mg/kg of the SORA1 (compound A) on 20% CO₂-induced changes in (c) SI in the SI test, and (f) line crossings and center time in the open field test. *, Between subjects differences using a Fisher’s LSD post hoc test that was protected with a repeated measures ANOVA and an ANOVA at each time point.