PET analysis. Summed uptake images (0–8 min, A) were normalized to the PET MNI image (B), and the normalization parameters applied to the summed emission image (C). The striatum region of interest was defined as 1,000 voxels with peak radioactivity (D). The ROI is shown in grey on the summed image, with the box surrounding it displaying the search area for the top 1,000. [Color figure can be viewed in the online issue, which is available at http://wileyonlinelibrary.com.]