Table 3.

Crude and adjusted associations of individual predictors with the rate of change in depressive symptoms

	Crude Model1 (n=2933)			Adjusted Model2 (n=2700)
Circadian Activity Rhythm Latent Class	Predictor * Time			Predictor * Time
	β	SE	p	β	SE	p
Normal rhythm	Reference			Reference
Low activity	0.10	0.03	0.0004	0.04	0.03	0.21
Early activity	−0.01	0.03	0.66	−0.02	0.03	0.47
Early/short active period	0.03	0.03	0.34	0.01	0.03	0.65
Early/short active period/dampened	0.13	0.03	<0.0001	0.09	0.03	0.01
Late activity	0.05	0.02	0.02	0.05	0.02	0.03
Late/short active period	0.12	0.03	<0.0001	0.06	0.03	0.03
Late with low activity	0.13	0.03	<0.0001	0.07	0.03	0.02

¹Adjusted for: age and study site;

²Adjusted for: age, study site, baseline depression severity, BMI, self-reported physical activity, cognitive function, anxiety symptoms, self-reported sleep quality, % time in rapid eye movement sleep, stressful events (loss of a pet, separated from child who is depended on, serious financial trouble, anything else), social factors (weekly participation in group, number of relatives), chronic diseases (IADL Impairment, COPD, Fall in past 12 months, diabetes, Parkinson’s, severe SDB), medication use (antidepressant use, benzodiazepine use, non-benzodiazepine non-barbiturate sedatives/hypnotics)