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. 2015 Dec;185(12):3274–3289. doi: 10.1016/j.ajpath.2015.08.019

Figure 3.

Figure 3

Increased injury in γ-catenin knockout (KO) mice after bile duct ligation (BDL). A: Serum alanine transaminase (ALT) and alkaline phosphatase (ALP) show a significant increase in KO mice after BDL. [Mean ALT for KO = 448.8 IU/L, wild type (WT) = 251.3 IU/L; mean ALP for KO mice = 780.6 IU/L, WT = 530.2 IU/L.] B: Immunohistochemistry (IHC) for terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) shows more cell death in KO liver after BDL. C: Sirius red staining shows greater collagen deposition in KO livers after BDL. D: Quantification of Sirius red staining shows greater area stained in KO livers after BDL (WT = 1.0%, KO = 4.1%). E: IHC for CK19 shows a greater biliary ductular reaction in KO livers after BDL. F: Quantification of CK19 staining shows a significant increase in CK19-positive ducts in KO livers compared with WT after BDL (KO = 5.6%, WT = 2.9%). *P < 0.05, **P < 0.01.