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. 2016 Feb;186(2):242–247. doi: 10.1016/j.ajpath.2015.10.003

Figure 1.

Figure 1

Down-regulation of serum levels of miR-30e and miR-223. Scatter plot of serum miRNA levels of miR-30e (A) and miR-223 (B) in healthy volunteers (HVs) and hepatocellular carcinoma (HCC) patients. The line indicates the median value per group. Fold-regulation values are expressed as relative quantification on the basis of 2ΔΔCt method. A U test was used to determine statistical significance. Receiver operating characteristic (ROC) curve was analyzed using serum miR-30e and miR-223 for discriminating HCC patients. ROC curves with corresponding area under the ROC curve (AUC) for miR-30e (C) and miR-223 (D) in discriminating HCC patients from HVs. Scatter plot of serum levels of miR-30e (E) and miR-223 (F) in chronic liver disease (CLD) and HCC patients. ROC curves with corresponding AUC for miR-30e (G) and miR-223 (H) in discriminating HCC patients from CLD. Data are presented as means ± SD. n = 14 (A and B, healthy volunteers); n = 39 (A, B, E, and F, HCC patients); n = 17 (E and F, CLD patients). ∗∗P < 0.01, ∗∗∗P < 0.001.