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. 2015 Dec;185(12):3141–3151. doi: 10.1016/j.ajpath.2015.08.020

Figure 2.

Figure 2

Deletion of miR-223 protects against Fas-induced caspase activation and poly (ADP-ribose) polymerase (PARP) cleavage. A: Wild-type (WT) and miR-223 KO mice were i.p. injected with 0.5 μg/g body weight Jo2. The liver tissues were harvested 0, 4, and 6 hours after Jo2 injection and processed for caspase (Casp) activity assays. The levels of caspase-3, caspase-8, and caspase-9 in miR-223 knockout (KO) livers are significantly lower compared with WT livers. B: Western blot analysis of liver tissue samples for caspase-3, caspase-8, and caspase-9 and PARP. Jo2 induces less cleavage of caspase-3, caspase-8, caspase-9, and PARP in miR-223 mice compared with WT mice. The result represents three individual experiments. The results represent means ± SD of fold changes (A). N = 6 per group (A). ∗P < 0.05, ∗∗P < 0.01.