Skip to main content
. 2015 Dec;185(12):3141–3151. doi: 10.1016/j.ajpath.2015.08.020

Figure 8.

Figure 8

Insulin-like growth factor 1 receptor (IGF1R) overexpression protects wild-type (WT) mice against Fas-induced liver injury. WT mice received 20 μg/mL of IGF1R expression plasmid (pBabe-bleo-IGF1R) or control plasmid via hydrodynamic tail vein injection. Forty-eight hours after tail vein injection, the mice were treated with 0.5 μg/g body weight of Jo2 via i.p. injection. A: Serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. IGF1R overexpression attenuates Jo2-induced transaminase increase. B: Caspase-3 and caspase-8 activities in the liver tissues. IGF1R overexpression attenuates Jo2-induced activation of caspase-3 and caspase-8. C: Immunostaining for activated caspase-3 in the liver tissues. The bar graph shows percentages of caspase-3–positive cells. ∗P < 0.05, ∗∗P < 0.01. Original magnification, ×100 (C). Vc, vector control plasmid.