Table 4. The mean primary pharmacokinetic parameters of MPA in 12 healthy volunteers following oral administration of 500 mg test and reference products.

PK Parameter	Cmax (µg /ml)		tmax (hr)		AUC0-24 (µg .hr/ml)		AUC0-∞ (µg .hr/ml)
Volunteer Code	test	reference	test	reference	test	reference	test	reference
A-Gh	4.89	4.88	3.00	3.50	52.14	52.20	59.00	59.36
S-R	4.85	4.87	5.00	3.50	44.60	44.10	77.56	72.15
H-M	7.21	6.23	5.00	4.00	56.67	54.85	77.02	75.54
B-Kh	3.76	3.78	5.00	3.00	34.86	35.62	40.92	41.86
S-N	3.48	3.61	5.50	3.50	33.52	37.58	34.88	39.26
A-Ch	4.85	4.89	4.00	4.50	45.56	42.47	79.32	55.77
K-D	4.85	4.76	4.50	4.50	46.83	39.69	60.32	47.38
Ah-M	4.87	5.12	6.00	3.00	40.71	41.69	62.53	57.20
Ar-L	3.47	3.68	3.00	4.50	32.45	34.60	33.12	35.44
E-S	4.65	4.64	4.00	4.50	49.65	48.64	93.38	51.87
E-O	6.74	5.76	4.00	5.50	51.95	50.34	71.56	70.36
M-E	4.65	5.03	3.50	4.00	49.47	49.20	56.43	98.32
Mean	4.86	4.77	4.38	4.00	44.87	44.25	62.17	58.71
SD	1.14	0.79	0.96	0.74	7.93	6.74	18.83	17.99
CV%	23.37	16.58	21.86	18.46	17.67	15.22	30.29	30.64
Max	7.21	6.23	6.00	5.50	56.67	54.85	93.38	98.32
Min	3.47	3.61	3.00	3.00	32.45	34.60	33.12	35.44
P value1	0.829		0.294		0.839		0.649