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Domain structure of fibrillin-1 (top) and relevant ADAMTS proteins (bottom). Above the fibrillin-1 domain structure are illustrated binding sites for the indicated molecules. The locations of fibrillin-1 mutations identified in WMS, SSS and GD are shown below the fibrillin-1 domain structure. Abbreviations not explained in the text: TE tropoelastin, NN fibrillin-1 N-terminus to fibrillin-1 N-terminus interaction, NC fibrillin-1 N-terminus to fibrillin-1 C-terminus interaction
