Table 3. Stability summary of unmodified, phosholipid-PEG, and Pluronic liposomes with varying degree of modification against chitosan derivative induced aggregation^a.

Formulation	+ MGCb	+ GCc	+ COd
CRX-601 unmodified liposomes	Aggregation	Aggregation	Aggregation
Phospholipid-PEG modified liposomes
CRX-601/PE-PEG2K liposome	Stable at ≥ 1% modificatione	Aggregation	Stable at ≥ 5% modification
CRX-601/PE-PEG5K liposome	Stable at ≥ 1% modification	Stable at ≥ 5% modification	Stable at ≥ 1% modification
Pluronic modified liposomes
CRX-601 /L64 liposomes	Aggregation	Aggregation	Aggregation
CRX-601/F68 liposomes	Aggregation	Aggregation	Aggregation
CRX-601/F127 liposome	Stable at ≥ 5% modification	Aggregation	Stable at ≥ 5% modification

^aThe lowest modification tested was 1 mol%

^ePartial aggregation 0.2 – 0.6 mg/mL

^bMGC: Methylglycol chitosan

^cGC: Glycol chitosan

^dCO: Chitosan oligosaccharide lactate