Skip to main content
. Author manuscript; available in PMC: 2016 Jan 27.
Published in final edited form as: Pharm Res. 2011 Dec 20;29(4):1098–1109. doi: 10.1007/s11095-011-0654-8

Fig. 1.

Fig. 1

Bcr-Abl domains and the targeting regions of the binding domains. Numbering indicates amino acidresidue location of each domain in Bcr-Abl (asterisk indicates approximate location). CCmut3 binds the coiled-coil domain, DBI binds the DHPH domains, RINI binds the SH3/SH2 domains, and ABI binds the ABD. CC = coiled-coil domain, S/T kinase = serine/threonine kinase domain, DH #x003; Dbl homology domain, PH = pleckstrin homology domain, SH3 = Src homology 3 domain, SH2 = Src homology 2 domain, Y kinase = tyrosine kinase domain, DBD = DNA binding domain, ABD = actin binding domain, CCmut3 = coiled-coil mutation set 3, RINI = Abl binding domain from RINI, DBI = DHPH binding iDab, ABI = ABD binding iDab, Red P = phosphorylation site.