hAR and PB-ARE-2 with glucocorticosteroids. Activity of the PB-ARE-2 promoter (luc) driven by hAR in COS-7 cells transfected with the promoter PB-ARE-2 and hAR after 24-h treatment with the glucocorticosteroids dexamethasone (DEX) and cortisol (COR) [4 doses, 100 nM (black bars), 50 nM (medium grey bars), 10 nM (dark grey bars), and 1 nM (light grey bars)], and ethanol vehicle (VEH). Columns represent the mean fold induction of three independent experiments run in triplicateError bars represent ± S.D. Significant difference from vehicle indicated with *, p < 0.05.