Figure 8. Ex vivo proliferation of T cells from mice immunized with MOG_35–55.

Mice were immunized with MOG_35–55/CFA, and spleen cells were isolated on d 10. Thymidine incorporation was measured 72 h upon culture of (A) spleen cells and (B) CD3⁺-enriched T cells cocultured with irradiated APCs in the presence of MOG_35–55. Data are shown as means ± sem and are representative of 2 independent experiments with similar results (n = 5 mice/genotype/experiment). *P < 0.05.