Table 3.

Associations of major depressive disorder features and personal risk factors with the likelihood of major depression, and anxiety disorder comorbidity latent class membership analyzed in univariate regression.

Risk Factor	MD1	Low Anxiety Class2	Agoraphobia Class2	Pan-anxiety Class2	Specific Phobia Class2	GAD Class2
Age of MD Onset*	-	1 (Ref.)	0.98 (0.77–1.26)	0.82 (0.65–1.03)	0.96 (0.84–1.10)	0.77 (0.66–0.89)
# of MD Episodes*	-	1 (Ref.)	1.15 (0.95–1.40)	1.23 (1.06–1.43)	1.16 (0.99–1.26)	1.06 (0.91–1.23)
# of MD Criteria*	-	1 (Ref.)	1.42 (1.05–1.92)	1.70 (1.24–2.33)	1.24 (1.08–1.44)	1.28 (1.09–1.51)
FH of MD Ratio*	-	1 (Ref.)	1.19 (0.95–1.50)	1.45 (1.23–1.71)	1.22 (1.07–1.39)	1.18 (1.03–1.37)
Neuroticism*	8.69 (7.78–9.74)	1 (Ref.)	1.72 (1.28–2.32)	3.49 (2.29–4.89)	1.75 (1.48–2.06)	1.85 (1.55–2.21)
Severe CSA	5.48 (3.95–7.78)	1 (Ref.)	1.48 (0.65–3.36)	2.19 (1.13–4.23)	1.41 (0.88–2.25)	1.54 (0.95–2.50)
Stressful Life Events*	1.56 (1.47–1.67)	1 (Ref.)	1.50 (1.23–1.84)	1.73 (1.45–2.06)	1.43 (1.27–1.61)	1.32 (1.16–1.51)
Maternal Warmth*	0.63 (0.59–0.67)	1 (Ref.)	0.95 (0.75–1.19)	0.95 (0.77–1.18)	0.99 (0.87–1.12)	0.94 (0.82–1.07)
Paternal Warmth*	0.60 (0.56–0.64)	1 (Ref.)	0.99 (0.78–1.24)	0.91 (0.74–1.13)	0.98 (0.87–1.11)	0.87 (0.76–0.99)

Binary (for MD) and multinomial (for class membership) logistic regression risk ratios are presented with 99.64% confidence intervals (adjusted conservatively for 14 independent tests). Bold results are significant at this threshold.

¹Sample size for binary logistic regression predicting MD status with psychosocial risk factors, including all individuals with valid data, is 11,647.

²Sample size for multinomial logistic regression predicting anxiety comorbidity latent class membership with MD clinical features and psychosocial risk factors, including only MD cases with valid data, is 5,864.

^*indicates a standardized variable.