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. Author manuscript; available in PMC: 2016 Feb 1.
Published in final edited form as: Pharmacogenomics J. 2015 Apr 14;16(1):54–59. doi: 10.1038/tpj.2015.23

Figure 1.

Figure 1

Associations between SLCO1B1*1b and absolute neutrophil count (ANC) nadir (a), UGT1A1*93 and ANC nadir (b) and ABCC2 -24C>T and log10 irinotecan area under the concentration–time curve (AUC0-24) (c) in the replication cohort. For the purpose of illustrating the replicated genetic associations, the data are not adjusted for the same factors used in the univariate analyses, and the differences among genotypes might not be the same as the ones reported in Table 2. ANC nadir is normalized to the baseline pretreatment ANC. Data are expressed as medians, 25th and 75th percentiles, minimums and maximums.