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Cytotoxicity of SLNPs and DC-Chol/DOPE liposomes with negative control siRNA. PC-3 cells were incubated for 4 h with liposomes of MA-Chol:DOPE (1:1) and DC-Chol:DOPE (1:1) encapsulating the same amount of negative control siRNA and assayed 48 h later. MA-Chol:DOPE liposomes did not show any notable toxicity, whereas DC-Chol:DOPE exhibited dose-related cytotoxicity, even at low lipid concentrations. The results represent mean ± s.e. (n=9).
