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. 2016 Jan 1;6(2):192–203. doi: 10.7150/thno.13657

Figure 4.

Figure 4

In vitro efficacy and gene silencing of siKSP@SLNPs in human SK-OV-3, AGS, and U87MG cancer cell lines. Cells were treated with siKSP(100 nM)@SLNPs for 4 h and assayed after 48 h. (A) KSP mRNA levels analyzed by qRT-PCR 48 h after transfection. KSP mRNA expression was notably knocked down in siKSP@SLNPs-treated cells. Results shown are mean ± s.e. (n=6). ***p < 0.001. (B) Cell viability assays, showing that siKSP@SLNPs were significantly more cytotoxic than controls. Results shown are means ± s.e. (n=9). ***p < 0.001.