Table 5.
Results of multivariable logistic-regression analysis of delayed vomiting and nausea among 380 women undergoing AC
| Variable | Odds ratioa (95 % CI) | P value |
|---|---|---|
| Delayed vomiting | ||
| Anti-emetic prophylaxis (1-day vs. 3-day regimen)b | 3.28 (1.43–7.52) | 0.005 |
| Age (<50 vs. ≥50 years) | 1.23 (0.50–3.03) | 0.653 |
| Interaction (anti-emetic prophylaxis) (age) | 0.32 (0.09–1.06) | 0.062 |
| Alcohol consumption (never vs. regularly) | 0.42 (0.15–1.13) | 0.085 |
| Acute vomiting (yes vs. no) | 3.48 (1.65–7.33) | 0.001 |
| Acute moderate-to-severe nausea (yes vs. no) | 3.41 (1.66–7.00) | 0.0009 |
| Delayed nausea (moderate-to-severe or mild) | ||
| Anti-emetic prophylaxis (1-day vs. 3-day regimen)b | 1.56 (1.00–2.43) | 0.050 |
| Age (<50 vs. ≥50 years) | 1.29 (0.82–2.02) | 0.271 |
| Alcohol consumption (never vs. regularly) | 0.76 (0.33–1.75) | 0.521 |
| Acute vomiting (yes vs. no) | 1.07 (0.50–2.33) | 0.853 |
| Acute moderate-to-severe nausea (yes vs. no) | 11.6 (4.94–27.2) | <0.0001 |
AC anthracycline plus cyclophosphamide, CI confidence interval
aAn odds ratio larger than 1 indicates an increased likelihood of experiencing delayed vomiting or nausea
bPatients received palonosetron plus dexamethasone on day 1 either with or without dexamethasone on days 2 and 3