Fig. 3.

Combined clinical and endoscopic remission rates at week 8 in the CORE I (a) and CORE II (b) studies. Clinical and endoscopic remission was defined as a UCDAI score ≤1, with scores of 0 for rectal bleeding and stool frequency, no mucosal friability on colonoscopy, and a reduction from baseline of ≥1 point in endoscopic index score. CI confidence interval, CIR controlled ileal release. Reprinted with permission from Sandborn et al. [15] and Travis et al. [16]