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. 2016 Jan 25;3(1):ENEURO.0067-15.2015. doi: 10.1523/ENEURO.0067-15.2015

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Copyright © 2016 Zucca et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 1. — Experimental setup, cerebellar circuit diagram, and single unit records. A, Schematic illustration of the experimental setup with recording and stimulation sites. mf, Mossy fiber; cf, climbing fiber; pf, parallel fiber; PC, Purkinje cell; GrC, granule cell; CN, cerebellar nuclei; IO, inferior olive; SC, superior colliculus. B, Complex spikes evoked by climbing fiber stimulation. Thin black traces represent ten superimposed complex spikes. Thick trace is the average waveform. The asterisk indicates the onset of the complex spike and the black arrow indicates the time of the stimulation. C, Extracellular recording of a representative Purkinje cell. Bottom trace shows an unfiltered recording and the inset shows, in greater detail, the complex spike evoked by climbing fiber stimulation. D, Archetypal interspike interval distribution before the start of the climbing fiber stimulation.