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. 2016 Jan 8;7:10002. doi: 10.1038/ncomms10002

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(a) Fluid-pulse stimulation (20 p.s.i., 80 ms) elicited action potential responses in control conditions (black) in the presence of gabazine (20 μM), AP5 (100 μM) and NBQX (40 μM). Application of the ASIC3 blocker APETx2 (2 μM) abolished responses (blue), which partially recovered upon washout (green). (b) Raster plot showing reliable responses to pressure stimulations (20 p.s.i., 80 ms) in control, and which were completely abolished by application of APETx2. Responses reappeared upon washout. (c) The receptor potential elicited by fluid pulses (20 p.s.i., 60 ms) was also blocked by APETx2 in the presence of TTX (1.5 μM). (d) Complete blockade of responses after application of APETx2 (n=6). Means±s.e.m.