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. 2016 Jan 28;7:15. doi: 10.3389/fphys.2016.00015

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Copyright © 2016 Cavalcanti, Alves, Oliveira, Cruz, França-Silva, Braga and Balarini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sildenafil reduces blood pressure in hypertensive rats. (A) Representative tracings from one animal of each group (Sham + vehicle, Sham + sildenafil, 2K1C + vehicle, and 2K1C + sildenafil) showing pulsatile arterial pressure (PAP), mean arterial pressure (MAP), and heart rate (HR). (B) Effect of sildenafil treatment during 7 days on MAP (a, p < 0.01 vs. sham + vehicle; b, p < 0.01 vs. sham + sildenafil; c, p < 0.05 vs. sham + vehicle; d, p < 0.01 vs. 2K1C + vehicle). (C) Effect of sildenafil treatment during 7 days on HR.