Table 3.
miRNA–mRNA pairs predictive of overall survival in AML Patients (data from TCGA).
| miRNA–mRNA Pair |
miRNA–mRNA correlation |
mRNA-risk group |
mRNA-OS |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Spearman Correlation |
Kruskal–Wallis |
Unstratified Cox model |
||||||||
| miRNA | mRNA probe | mRNA gene | mRNA Chr | r | p-value | p-value | FDR | HR | p-value | FDR |
| mir-107 | 212202_s_at | TMEM87A | chr15q15.1 | -0.208 | 0.004 | 0.000 | 0.001 | 0.386 | 0.000 | 0.045 |
| mir-107 | 204798_at | MYB | chr6q23.3 | -0.235 | 0.001 | 0.050 | 0.075 | 0.430 | 0.000 | 0.004 |
| mir-10a | 201724_s_at | GALNT1 | chr18q12.2 | -0.418 | 0.000 | 0.000 | 0.000 | 0.327 | 0.000 | 0.006 |
| mir-10a | 218181_s_at | MAP4K4 | chr2q11.2 | -0.445 | 0.000 | 0.046 | 0.072 | 0.558 | 0.001 | 0.045 |
| mir-10a | 222273_at | PAPOLG | chr2p16.1 | -0.174 | 0.018 | 0.429 | 0.350 | 0.392 | 0.000 | 0.013 |
| mir-148b | 218181_s_at | MAP4K4 | chr2q11.2 | 0.240 | 0.001 | 0.046 | 0.072 | 0.558 | 0.001 | 0.045 |
| mir-16 | 213150_at | HOXA10∗ | chr7p15.2 | 0.441 | 0.000 | 0.000 | 0.000 | 1.216 | 0.000 | 0.041 |
| mir-16 | 201724_s_at | GALNT1 | chr18q12.2 | -0.217 | 0.003 | 0.000 | 0.000 | 0.327 | 0.000 | 0.006 |
| mir-16 | 212314_at | SEL1L3 | chr4p15.2 | 0.263 | 0.000 | 0.000 | 0.000 | 1.446 | 0.001 | 0.046 |
| mir-16 | 209193_at | PIM1 | chr6p21.2 | 0.247 | 0.001 | 0.002 | 0.006 | 1.713 | 0.000 | 0.045 |
| mir-196a | 214651_s_at | HOXA9∗ | chr7p15.2 | 0.293 | 0.000 | 0.000 | 0.000 | 1.166 | 0.001 | 0.046 |
| mir-196a | 204779_s_at | HOXB7 | chr17q21.32 | 0.223 | 0.002 | 0.000 | 0.000 | 1.276 | 0.001 | 0.046 |
| mir-196a | 201852_x_at | COL3A1 | chr2q32.2 | 0.252 | 0.001 | 0.152 | 0.170 | 0.783 | 0.000 | 0.045 |
| mir-196a | 213687_s_at | RPL35A | chr 3q29 | -0.174 | 0.018 | 0.300 | 0.276 | 0.399 | 0.000 | 0.042 |
| mir-197 | 212202_s_at | TMEM87A | chr15q15.1 | -0.184 | 0.012 | 0.000 | 0.001 | 0.386 | 0.000 | 0.045 |
| mir-197 | 218181_s_at | MAP4K4 | chr2q11.2 | 0.159 | 0.030 | 0.046 | 0.072 | 0.558 | 0.001 | 0.045 |
| mir-29b | 207106_s_at | LTK∗ | chr15q15.1 | -0.184 | 0.012 | 0.000 | 0.000 | 0.790 | 0.001 | 0.046 |
| mir-29b | 56919_at | WDR48 | chr3p22.2 | -0.169 | 0.021 | 0.068 | 0.095 | 0.514 | 0.000 | 0.009 |
| mir-30e | 204779_s_at | HOXB7 | chr17q21.32 | -0.325 | 0.000 | 0.000 | 0.000 | 1.276 | 0.001 | 0.046 |
| mir-30e | 201724_s_at | GALNT1 | chr18q12.2 | 0.208 | 0.004 | 0.000 | 0.000 | 0.327 | 0.000 | 0.006 |
| mir-30e | 218313_s_at | GALNT7 | chr4q34.1 | 0.329 | 0.000 | 0.106 | 0.132 | 0.417 | 0.000 | 0.024 |
| mir-378 | 210164_at | GZMB | chr14q12 | -0.205 | 0.005 | 0.199 | 0.207 | 1.439 | 0.001 | 0.046 |
| mir-421 | 214651_s_at | HOXA9∗ | chr7p15.2 | -0.277 | 0.000 | 0.000 | 0.000 | 1.166 | 0.001 | 0.046 |
∗Except for HOXA9, HOXA10, and LTK, all other genes were also significantly associated with OS (p < 0.05) in risk stratified analysis. FDR was estimated by Pounds and Cheng (2006) robust FDR method.
Bold indicates significance for p-value with p < 0.05 (Spearman Correlation and Kruskal–Wallis) and p < 0.001 (Unstratified Cox model).