Table 2.
Correlations between clinicopathological parameters and miRNAs expression in GC tissues
| Parameters | Patient | Median (25-75th) | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| miR-29c | P-value | miR-124 | P-value | miR-135a | P-value | miR-148a | P-value | ||
| Gender | |||||||||
| Female | 24 | 0.331 (0.143-1.000) | 0.497 | 0.023 (0.005-0.051) | 0.051 | 0.052 (0.017-0.227) | 0.325 | 0.529 (0.149-4.790) | 0.541 |
| Male | 36 | 0.351 (0.222-1.300) | 0.007 (0.003-0.025) | 0.031 (0.009-0.045) | 0.516 (0.164-1.454) | ||||
| Age | |||||||||
| < 60 | 32 | 0.232 (0.143-1.005) | 0.335 | 0.011 (0.001-0.038) | 0.059 | 0.028 (0.008-0.110) | 0.313 | 0.420 (0.143-2.023) | 0.750 |
| ≥ 60 | 28 | 0.416 (0.235-1.176) | 0.016 (0.007-0.029) | 0.036 (0.013-0.067) | 0.603 (0.166-1.174) | ||||
| Tumor location | |||||||||
| Upper third | 7 | 0.231 (0.079-0.237) | 0.136 | 0.004 (0.001-0.005) | 0.072 | 0.015 (0.009-0.031) | 0.234 | 0.230 (0.105-0.420) | 0.216 |
| Middle third | 16 | 0.240 (0.157-1.000) | 0.007 (0.004-0.029) | 0.038 (0.007-0.110) | 1.811 (0.132-6.421) | ||||
| Lower third | 37 | 0.467 (0.222-1.312) | 0.015 (0.007-0.037) | 0.036 (0.012-0.086) | 0.529 (0.164-1.369) | ||||
| Tumor size | |||||||||
| < 5 cm | 45 | 0.351 (0.222-1.120) | 0.602 | 0.013 (0.004-0.038) | 0.174 | 0.036 (0.012-0.110) | 0.286 | 0.529 (0.164-1.454) | 0.746 |
| ≥ 5 cm | 15 | 0.235 (0.150-1.007) | 0.008 (0.004-0.018) | 0.024 (0.003-0.045) | 0.529 (0.218-2.085) | ||||
| Differentiation | |||||||||
| Well and moderately | 16 | 0.240 (0.119-2.458) | 0.881 | 0.015 (0.002-0.177) | 0.607 | 0.035 (0.006-0.202) | 0.496 | 0.566 (0.135-14.873) | 0.249 |
| Poorly | 44 | 0.409 (0.132-0.997) | 0.006 (0.003-0.016) | 0.017 (0.008-0.043) | 0.388 (0.118-1.266) | ||||
| Depth of invasion | |||||||||
| T3 | 41 | 0.351 (0.143-1.028) | 0.505 | 0.006 (0.002-0.029) | 0.824 | 0.024 (0.006-0.047) | 0.704 | 0.420 (0.123-1.454) | 0.899 |
| T4 | 15 | 0.235 (0.111-0.674) | 0.008 (0.002-0.029) | 0.014 (0.003-0.059) | 0.252 (0.122-1.283) | ||||
| Lymph node involvement | |||||||||
| Negative | 30 | 0.384 (0.234-1.240) | 0.088 | 0.027 (0.013-0.055) | 0.000 | 0.079 (0.024-0.153) | 0.000 | 0.725 (0.420-4.790) | 0.007 |
| Positive | 30 | 0.257 (0.099-0.971) | 0.005 (0.002-0.012) | 0.014 (0.005-0.037) | 0.251 (0.109-1.232) | ||||
| Tumor stage | |||||||||
| Ι-II | 32 | 0.384 (0.232-1.512) | 0.049 | 0.020 (0.007-0.038) | 0.003 | 0.040 (0.015-0.153) | 0.005 | 0.603 (0.268-1.516) | 0.065 |
| III-IV | 28 | 0.257 (0.088-0.997) | 0.005 (0.002-0.017) | 0.015 (0.005-0.051) | 0.304 (0.107-1.450) | ||||