Table 2.
Univariate and multivariate analysis of metastasis-free survival according to Cox’s proportional hazards model
| HNSCC tumors | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
|
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| Variable | Hazard ratio | 95% C.I. | P | Hazard ratio | 95% C.I. | P |
| Gender (male [n=191] v. female [n=34]) | 1.971 | 0.834-4.658 | 0.122 | 1.992 | 0.855-4.645 | 0.110 |
| Age. years (younger 58 years [n=114] v. older 58 years [n=111]) | 1.538 | 0.709-3.336 | 0.276 | 1.569 | 0.744-3.309 | 0.237 |
| T category (T1/T2 [n=110] v. T3/T4 [n=115]) | 3.106 | 1.314-7.341 | 0.010 | 3.491 | 1.565-7.787 | 0.002 |
| N category (N0 [n=81] v. N+ [n=144]) | 0.696 | 0.236-2.052 | 0.512 | --- | --- | --- |
| Stage (UICC I-III [n=70] v. UICC IV [n=155]) | 1.039 | 0.309-3.495 | 0.951 | --- | --- | --- |
| Grad (1 + 2 [n=145] v. 3 + 4 [n=80]) | 0.876 | 0.415-1.852 | 0.730 | --- | --- | --- |
| KPNA2 (low/negative [n=139] v. any high [n=86]) | 3.629 | 1.104-11.927 | 0.034 | 2.821 | 1.303-6.106 | 0.008 |
| KPNA2 (< 15% [n=115] v. ≥ 15% [n=110]) | 2.084 | 0.684-6.35 | 0.196 | 1.832 | 0.844-3.976 | 0.126 |
| KPNA2 (no cytoplasmic staining [n=120] v. positive [n=105]) | 1.249 | 0.363-4.298 | 0.725 | --- | --- | --- |