Table 3.
Univariate and multivariate analysis of no evidence of disease according to Cox’s proportional hazards model
| HNSCC tumor | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
|
|
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| Variable | Hazard ratio | 95% C.I. | P | Hazard ratio | 95% C.I. | P |
| Gender (male [n=191] v. female [n=34]) | 1.255 | 0.627-2.51 | 0.521 | --- | --- | --- |
| Age, years (younger 58 years [n=114] v. older 58 years [n=111]) | 0.842 | 0.493-1.438 | 0.529 | --- | --- | --- |
| T category (T1/T2 [n=110] v. T3/T4 [n=115]) | 1.710 | 0.967-3.023 | 0.065 | 1.580 | 0.941-2.652 | 0.083 |
| N category (N0 [n=81] v. N+ [n=144]) | 0.753 | 0.3-1.891 | 0.546 | 0.756 | 0.449-1.273 | 0.292 |
| Stage (UICC I [n=70] v. UICC II and higher [n=155]) | 1.013 | 0.37-2.776 | 0.980 | --- | --- | --- |
| Grad (1 + 2 [n=145] v. 3 + 4 [n=80]) | 0.866 | 0.501-1.497 | 0.606 | --- | --- | --- |
| KPNA2 (low/low [n=139] v. any high [n=86]) | 0.634 | 0.266-1.511 | 0.304 | 0.577 | 0.342-0.974 | 0.039 |
| KPNA2 (< 15% [n=115] v. ≥ 15% [n=110]) | 0.902 | 0.413-1.974 | 0.797 | --- | --- | --- |
| KPNA2 (no cytoplasmic staining [n=120] v. positive [n=105]) | 0.886 | 0.452-1.738 | 0.725 | --- | --- | --- |