Effect of rubriflordilactone on the acute lung injury induced in rats by LPS administration. A. The pulmonary tissues of the rats in LPS, LPS+Rub and control groups were stained with HE-stain (magnification, ×200). B. Rubriflordilactone treatment increased expression of Sirt1 significantly compared to LPS group was analyzed by immunohistochemistry. Rub, LPS and Sirt1 stand for rubriflordilactone, lipopolysaccharide and sirtuin 1, respectively.