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. 2015 Dec 25;5(1):2. doi: 10.3390/jcm5010002

Figure 1.

Figure 1

A schematic representation of the miRNA clusters dysregulated in human breast CSCs. The miRNAs sharing the same seed sequence (nucleotides from two to seven) are marked by the same color. The mammalian miR-200 clusters are expressed as two separate polycistronic pri-miRNA transcripts. The miRNAs coded in the miR-200b-200a-429, miR-200c-141 and miR-183-96-182 clusters are downregulated, and those in the miR-221-222 cluster are upregulated in the human breast CSCs. The arrows indicate the direction of the pri-miRNA transcription.