Table 3. Risk of outcomes among subjects with stage 3-4 and stage 5 CKD by HbA1c level.
|
All |
CKD stage 3-4 |
CKD stage 5 |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HbA1c level (%) | HbA1c level (%) | HbA1c level (%) | ||||||||||
| <6 | 6–7 | 7–9 | >9 | <6 | 6–7 | 7–9 | >9 | <6 | 6–7 | 7–9 | >9 | |
| HR (95% CI) for RRT | ||||||||||||
| Unadjusted | 1 | 0.79 (0.65–0.96)* | 0.79 (0.65–0.95)* | 0.64 (0.51–0.82)** | 1 | 0.76 (0.51–1.13) | 1.12 (0.79–1.60) | 1.30 (0.89–1.91) | 1 | 1.15 (0.92–1.45) | 1.10 (0.88–1.38) | 0.92 (0.64–1.31) |
| Adjusteda | 1 | 1.16 (0.95–1.41) | 1.22 (1.01–1.49)* | 1.11 (0.86–1.42) | 1 | 1.20 (0.80–1.80) | 1.38 (0.96–1.99) | 1.60 (1.07–2.38)* | 1 | 1.14 (0.90–1.44) | 1.28 (1.01–1.63)* | 1.01 (0.70–1.45) |
| HR (95% CI) for all-cause mortality | ||||||||||||
| Unadjusted | 1 | 1.05 (0.80–1.38) | 1.10 (0.85–1.43) | 0.92 (0.66–1.27) | 1 | 1.11 (0.74–1.68) | 1.21 (0.82–1.79) | 1.22 (0.79–1.88) | 1 | 1.12 (0.78–1.62) | 1.24 (0.87–1.77) | 0.92 (0.51–1.67) |
| Adjusteda | 1 | 1.26 (0.96–1.66) | 1.29 (0.99–1.68) | 1.30 (0.93–1.83) | 1 | 1.46 (0.96–2.21) | 1.35 (0.91–2.02) | 1.52 (0.97–2.38) | 1 | 1.09 (0.75–1.57) | 1.16 (0.80–1.67) | 0.97 (0.53–1.79) |
| HR (95% CI) for CV event | ||||||||||||
| Unadjusted | 1 | 0.86 (0.66–1.12) | 0.85 (0.66–1.09) | 0.86 (0.63–1.17) | 1 | 0.83 (0.56–1.22) | 0.99 (0.69–1.41) | 1.01 (0.67–1.52) | 1 | 1.02 (0.71–1.46) | 0.86 (0.59–1.25) | 1.12 (0.65–1.91) |
| Adjusteda | 1 | 0.99 (0.76–1.29) | 0.97 (0.74–1.25) | 1.11 (0.80–1.54) | 1 | 1.02 (0.69–1.51) | 1.14 (0.79–1.64) | 1.16 (0.76–1.76) | 1 | 1.04 (0.72–1.50) | 0.82 (0.56–1.22) | 1.13 (0.64–1.98) |
| HR (95% CI) for CV event + all cause mortality | ||||||||||||
| Unadjusted | 1 | 0.88 (0.71–1.10) | 0.92 (0.74–1.14) | 0.91 (0.70–1.18) | 1 | 0.96 (0.68–1.34) | 1.10 (0.80–1.50) | 1.23 (0.87–1.75) | 1 | 0.94 (0.70–1.27) | 0.98 (0.73–1.31) | 1.04 (0.67–1.62) |
| Adjusteda | 1 | 1.04 (0.84–1.31) | 1.06 (0.85–1.31) | 1.25 (0.95–1.63) | 1 | 1.25 (0.89–1.76) | 1.29 (0.93–1.77) | 1.46 (1.02–2.09)* | 1 | 0.93 (0.69–1.25) | 0.91 (0.67–1.23) | 1.07 (0.68–1.69) |
aThe Cox proportional hazard model was adjusted for age, gender, estimated glomerular filtration rate, log (urine protein-to-creatinine ratio), cardiovascular disease, mean blood pressure, hemoglobin, albumin, log (cholesterol), log (C-reactive protein), phosphorus and body mass index.
*p < 0.05 and **p < 0.001 indicate significantly different with reference group.