Table 2. IC₅₀ Values for Inhibitors for CLK Family Members^a.

	TG003	NR9	3A5	5E4	5F4
CLK1 (nM)	49	390	51	277	273
CLK2 (nM)	353	553	68	174	127
CLK3 (nM)	>3000	>3000	346	>3000	>3000
DYRK1A (nM)	204	596	260	334	213

^aIC₅₀ values were determined for the five inhibitors for CLK1, CLK2, CLK3, and DYRK1A. Literature values for TG003 according to Muraki et al.:²¹ CLK1, 20 nM; CLK2, 200 nM; CLK3, >10 μM; CLK4, 15 nM. Literature values for TG003 according to Fedorov et al.:¹⁴ CLK1, 48.6 nM; CLK3, >4 μM; Dyrk1A, 156.1 nM. Literature values for TG003 according to Mott et al.:²⁶ CLK1, 19 nM; CLK2, 95 nM; CLK3, 3 μM; CLK4, 30 nM; Dyrk1A, 12 nM.