Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic representation of the cholesterol pathway and of the mediation of sterol metabolites (ubiquinone) in mitochondrial respiratory function (Complex I–IV) in response to the inflammation signal. Inhibitors of CP and MTAse (as MitoQ) are indicated in capital and red characters: statins, aminobisphosphonate, squalene synthase and farnesyltransferase inhibitors. The block of CP leads to the activation of the NLRP3 inflammasome and consequently IL-1β through mitochondrial signals.
