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. 2015 Dec 31;17(1):54. doi: 10.3390/ijms17010054

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Kinetics of (a) 50 and (b) 100 nm SPION uptake by CHO-K1 cells, represented by (1) Average grading of particles, after 30 min, 4, 24, and 72 h of incubation. Grade 0 = no blue color, grade 1 = faint blue staining in cytoplasm, grade 2 = dense blue color in minor portions of cytoplasm (less than 50%), grade 3 = deep blue staining in most cytoplasm (>50%) and grade 4 = cell filled with intense, dark blue througout; and (2) Quantitfication of internalized iron using a ferrozine assay is reported below the histograms, with evolution of the quantitative uptake over time. Hollow markers indicate concentrations below the detection limit of the assay (i.e., zeros).

Inline graphic — Kinetics of (a) 50 and (b) 100 nm SPION uptake by CHO-K1 cells, represented by (1) Average grading of particles, after 30 min, 4, 24, and 72 h of incubation. Grade 0 = no blue color, grade 1 = faint blue staining in cytoplasm, grade 2 = dense blue color in minor portions of cytoplasm (less than 50%), grade 3 = deep blue staining in most cytoplasm (>50%) and grade 4 = cell filled with intense, dark blue througout; and (2) Quantitfication of internalized iron using a ferrozine assay is reported below the histograms, with evolution of the quantitative uptake over time. Hollow markers indicate concentrations below the detection limit of the assay (i.e., zeros).