Table 1.
Mean hydrodynamic diameter (HD) and ζ-potential (ZP) of superparamagnetic iron-oxide nanoparticles (SPIONs) in deionized water and in Ham’s F-12K culture media supplemented with 10% FBS.
| Sample | In Deionized Water, at 37 °C | In Supplemented Ham‘s F-12K Cultre Media, at 37 °C | |||||||
|---|---|---|---|---|---|---|---|---|---|
| HD (nm) | PdI | ZP (mV) | 1 h | 24 h | 72 h | ||||
| HD (nm) | PdI | HD (nm) | PdI | HD (nm) | PdI | ||||
| 50 nm SPIONs | |||||||||
| Starch-coated | 47 ± 1 | 0.12 | −23 ± 3 | 36 ± 1 | 0.25 | 68 ± 2 | 0.28 | 148 ± 4 | 0.30 |
| Aminated | 90 ± 2 | 0.18 | +13 ± 1 | 57 ± 1 | 0.32 | 55 ± 5 | 0.38 | 50 ± 3 | 0.38 |
| 2k-PEG | 72 ± 3 | 0.20 | +36 ± 1 | 41 ± 1 | 0.30 | 40 ± 1 | 0.30 | 40 ± 1 | 0.31 |
| 5k-PEG | 71 ± 1 | 0.20 | +34 ± 1 | 37 ± 2 | 0.42 | 36 ± 2 | 0.41 | 36 ± 2 | 0.44 |
| 20k-PEG | 72 ± 4 | 0.20 | +33 ± 2 | 35 ± 1 | 0.48 | 36 ± 1 | 0.47 | 33 ± 2 | 0.47 |
| 100 nm SPIONs | |||||||||
| Starch-coated | 92 ± 1 | 0.09 | −4 ± 1 | 117 ± 1 | 0.29 | 461 ± 4 | 0.70 | 1133 ± 30 | 0.19 |
| Aminated | 127 ± 5 | 0.17 | +43 ± 1 | 119 ± 4 | 0.30 | 110 ± 3 | 0.22 | 108 ± 3 | 0.22 |
| 2k-PEG | 117 ± 2 | 0.14 | +36 ± 1 | 93 ± 1 | 0.24 | 95 ± 3 | 0.23 | 95 ± 2 | 0.24 |
| 5k-PEG | 126 ± 4 | 0.14 | +37 ± 1 | 103 ± 2 | 0.25 | 102 ± 2 | 0.24 | 114 ± 2 | 0.29 |
| 20k-PEG | 154 ± 5 | 0.12 | +32 ± 1 | 122 ± 3 | 0.26 | 117 ± 3 | 0.26 | 146 ± 2 | 0.36 |
HD: hydrodynamic diameter (nm); ZP: ζ potential (mV); PdI: Polydispersity index; FBS: Fetal Bovine Serum; Results shown as mean ± std. error of mean.