Table 1.

Cytoskeletal interactions with members of the innate immune response.

Innate Immune Protein	Cytoskeleton Protein	Characterization of Interaction	Reference
Cytoskeleton regulated activation
NOD2	Rac1	Recruits NOD2 to membrane ruffles Actin depolymerization leads to activation and release to insoluble cell fraction	Legrand-Poels et al. [136]
RIG-I	Unknown	Localizes to tight junctions and membrane ruffles Actin depolymerization leads to relocalization to punctate domains and IFNβ induction	Mukherjee et al. [137]
MAVS	FAK	Virus infection induces FAK relocalization from focal adhesions to binding MAVS at the mitochondrion, inducing FAK-dependent IFNβ expression	Bozym et al. [139]
TBK1	GEF-H1	RLR activation induces GEF-H1 dephosphorylation, release from microtubules, and binding to TBK1	Chiang et al. [140]
Pyrin	Unknown	Actin polymerization induced by mutation of the Wdr1 depolymerizing factor activates the pyrin inflammasome to produce elevated IL-18	Kim et al. [135]
Caspase-1	Flightless	Inhibits caspase-1 activation and subsequent IL-1β maturation	Li et al. [141]
Innate regulation of the cytoskeleton
ASC	Dock2	ASC stabilizes Dock2 mRNA which mediates Rac-dependent actin polymerization	Ippagunta et al. [142]
RNase-L	Filamin A	RNase-L KO MEFs express decreased levels of polymerized actin RNase-L monomer binds to Filamin A to inhibit virus entry	Malathi et al. [28]
PKR	Gelsolin	Latent PKR inhibits gelsolin from severing actin filaments	Irving et al. [143]
Caspase-11	Aip1	Caspase-11 enhances Aip1-dependent actin polymerization	Li et al. [144]
ADAP2	Arf6	Induces membrane ruffling and macropinocytosis Associates with and controls actin dynamics Inhibits Dengue virus and VSV	Shu et al. [145]
Undetermined function of the interaction
IFITM1	Occludin, Claudin1, and ZO-1	Enhances the interaction between HCV receptors occludin and CD81, inhibiting virus entry	Wilkins et al. [146]
RNase-L	IQGAP1	Unknown	Sato et al. [120]
	LNX1	Unknown	Figure 2 and Figure 3