Figure 2.

Time course of a TSE infection; ME7/C57BL. The murine TSE strain, ME7 is intracerebrally inoculated into C57BL mice. The total incubation period in this model is approximately 24 weeks. PrP^Sc and gliosis can be detected from eight weeks post inoculation. This is followed by changes in behavioural signs (from 10 weeks), synaptic loss (from 12 weeks), neuronal loss (from 19 weeks) and overt clinical signs can be observed from approximately 20 weeks. Data in this figure was obtained from [62,63,67].