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. 2016 Jan 14;17(1):90. doi: 10.3390/ijms17010090

Figure 3.

Figure 3

A schematic representation of the chemotactic signaling pathways in mammalian neutrophils. In the presence of PIP3, Gβγ can directly activate GEFs for Rac and Cdc42, resulting in activated Rac and Cdc42 to promote F-actin polymerization and regulate cell motility of migrating neutrophils through the activation of WASP and SCAR/WAVE complex. During chemotaxis, several downstream effectors of Gα subunits have been identified: ELMO1/Dock180, p115RhoGEF, mTORC2, Homer-3 and LGN/AGS3-mInsc.