Table 2.
Histologic features of the patients with herb-induced liver injury.
| Histologic Features | 1 | 2 | 3 | 4 | 8 | 9 |
|---|---|---|---|---|---|---|
| Suspected herb | Ayurvedic herb | Hypericum perforatum | Valeriana | Valeriana | Valeriana | Valeriana |
| Necrosis | +++ | + | + | + | + | − |
| Necrosis localisation | Zone III | Disseminated | Disseminated | Zone III | Disseminated | Not applicable |
| Lobular inflammation | + | + | + | + | + | − |
| Portal inflammation | ++ | ++ | ++ | + | − | + |
| Plasma cells | ++ | − | + | ? | − | − |
| Eosinophils | + | + | − | ? | + | − |
| Neutrophils | ++ | − | + | ? | + | − |
| Lymphocytes | − | ++ | ++ | ? | − | + |
| Canalicular cholestasis | − | − | ++ | − | − | − |
? = no data available.