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. 2016 Jan 16;17(1):120. doi: 10.3390/ijms17010120

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© 2016 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) mRNA expression in meniscal cells with/without PRP. Aggrecan mRNA expression decreased in a time-dependent manner in PRP(+). Type II collagen gene expression decreased in PRP(+) compared to PRP(−) after Day 10. In initial examinations, MMP-3, MMP-9, and MMP-13 displayed increased expression in the PRP(+); (B) Protein expression analysis in culture media of meniscal cells with/without PRP. PRP(+) showed a relative upregulation in the protein levels of MMP-1, MMP-3, and TIMP-1 compared to PRP(−). * p < 0.05; ** p < 0.01 versus Day 3. ^# p < 0.05; ^## p < 0.01; ^### p < 0.001 versus PRP(−).

(A) mRNA expression in meniscal cells with/without PRP. Aggrecan mRNA expression decreased in a time-dependent manner in PRP(+). Type II collagen gene expression decreased in PRP(+) compared to PRP(−) after Day 10. In initial examinations, MMP-3, MMP-9, and MMP-13 displayed increased expression in the PRP(+); (B) Protein expression analysis in culture media of meniscal cells with/without PRP. PRP(+) showed a relative upregulation in the protein levels of MMP-1, MMP-3, and TIMP-1 compared to PRP(−). * p < 0.05; ** p < 0.01 versus Day 3. ^# p < 0.05; ^## p < 0.01; ^### p < 0.001 versus PRP(−).