Table 1.
Roles of different regulators on adipogenesis.
Regulator | Model | Effects | References |
---|---|---|---|
The Kruppel-like Factor Family | 3T3-L1 preadipocytes | Enhanced adipogenesis | [63,64,65,66] |
↑ C/EBPα, C/EBPβ, PPARγ expression | |||
Sterol Regulatory Element-binding Protein 1 | 3T3-L1 preadipocytes | Enhanced adipogenesis | [67,68,69] |
↑ FAS, LPL, and PPARγ expression | |||
Cyclic AMP Response Element-binding Protein | 3T3-L1 preadipocytes | Enhanced adipogenesis | [70] |
↑ PPARγ and FABP4 expression | |||
Zinc Finger Protein 423 | NIH-3T3 fibroblasts | Enhanced adipogenesis | [71] |
↑ PPARγ expression | |||
Bovine stromal vascular cells | Enhanced adipogenesis | [72] | |
↑ PPARγ and C/EBPα expression | |||
The Kruppel-like factor 2 | Mouse 3T3-L1 cell lines | Inhibited adipogenesis | [73] |
↓ PPARγ, C/EBPα, and SREBP1 expression | |||
GATA binding protein 2 and GATA binding protein 3 | Mouse preadipocytes | Inhibited adipogenesis | [74] |
↓ PPARγ expression | |||
3T3-F442A preadipocytes | Formation of protein complexes with C/EBPα and C/EBPβ | [75] | |
Preadipocyte factor-1 | 3T3-L1 preadipocytes | Inhibited adipogenesis | [76,77,78,79,80] |
↓ PPARγ, C/EBPα, FAS, SCD, and FABP4 expression | |||
Transcriptional-coactivator with PDZ-binding motif | C3H10T1/2 MSCs | Inhibited adipogenesis | [81,82] |
3T3-L1 preadipocytes | ↓ PPARγ expression | ||
The histone deacetylase Sirtuin 1 (SIRT1) | C3H10T1/2 MSCs | Inhibited adipogenesis | [83] |
↓ PPARγ expression | |||
3T3-L1 preadipocytes | Inhibited adipogenesis, | [84] | |
↓ C/EBP-α, C/EBP-δ and FABP4 expression |
↑ increase in expression; ↓ decrease in expression.